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PT 141 10mg
$65.00
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PT 141 10mg
PT-141 is a synthetic melanocortin receptor agonist structurally derived from the analog Melanotan II. It binds selectively to MC3R and MC4R, modulating neuropeptide signaling pathways involved in hypothalamic control mechanisms. PT-141 is commonly employed in research focusing on GPCR activation, neuronal signaling, and neuroendocrine modulation.
For research use only. Not for human consumption.
Properties
1. Basic Information
2. Structural Properties
Peptide Nature: Cyclic lactam peptide; differs from MT-II by free C-terminal carboxyl group instead of amide
Secondary Structure: Constrained cyclic conformation providing selectivity for MC4R over MC1R
Hydrophobicity: Moderately hydrophobic; similar profile to Melanotan II
Charge: Positively charged at physiological pH
3. Solubility
4. Stability
Thermal Stability: Stable under standard peptide storage conditions due to cyclic structure
Proteolytic Stability: D-Phe substitution and cyclic conformation confer enzymatic resistance
Storage: Store lyophilized at −20°C; reconstituted solution stable up to 30 days at 2–8°C
5. Chemical Reactivity
Free C-terminal carboxyl group distinguishes PT-141 from MT-II chemically
Tryptophan susceptible to oxidation; store protected from light
Lactam bridge stable under physiological conditions
N-terminal acetylation enhances metabolic stability
6. Other Properties
- Name: PT-141 (Bremelanotide)
- Type: Synthetic cyclic peptide analog of Melanotan II
- Length: 7 amino acids (cyclic)
- Sequence: Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH
- Molecular Weight: 1025.19 Da
- Formula: C₅₀H₆₉N₁₅O₁₀
- CAS Number: 189691-06-3
2. Structural Properties
Peptide Nature: Cyclic lactam peptide; differs from MT-II by free C-terminal carboxyl group instead of amide
Secondary Structure: Constrained cyclic conformation providing selectivity for MC4R over MC1R
Hydrophobicity: Moderately hydrophobic; similar profile to Melanotan II
Charge: Positively charged at physiological pH
3. Solubility
- Soluble in bacteriostatic water and dilute acetic acid
- Stable at slightly acidic to neutral pH
- Supplied as lyophilized powder for reconstitution
4. Stability
Thermal Stability: Stable under standard peptide storage conditions due to cyclic structure
Proteolytic Stability: D-Phe substitution and cyclic conformation confer enzymatic resistance
Storage: Store lyophilized at −20°C; reconstituted solution stable up to 30 days at 2–8°C
5. Chemical Reactivity
Free C-terminal carboxyl group distinguishes PT-141 from MT-II chemically
Tryptophan susceptible to oxidation; store protected from light
Lactam bridge stable under physiological conditions
N-terminal acetylation enhances metabolic stability
6. Other Properties
- MC4R selective: Greater selectivity for melanocortin-4 receptor compared to Melanotan II in binding studies
- Investigated in preclinical and clinical research models examining melanocortin signaling pathways
- Metabolic product: PT-141 is the active metabolite of Melanotan II following in vivo hydrolysis
Description
PT-141 (Bremelanotide) is a synthetic cyclic peptide and has been described in the scientific literature as a melanocortin receptor agonist with reported selectivity toward the MC4R subtype. Publications referencing PT-141 discuss it in the context of central melanocortin signaling and receptor pharmacology within experimental systems.
Reports involving PT-141 describe its binding characteristics at melanocortin receptor subtypes under defined experimental conditions. Observations of receptor activation and associated signaling components are limited to non-clinical research settings and are reported as descriptive findings within cellular and animal model studies.
All references to PT-141 are confined to mechanistic and observational research contexts and do not extend beyond laboratory-based investigation.
In the scientific literature, PT-141 has been referenced in non-clinical and early-phase clinical research involving receptor binding assays and animal model studies. These publications describe experimental contexts in which molecular interactions, signaling components, and pathway-associated markers were observed and recorded.
Reported research contexts include examination of:
- MC4R-selective binding dynamics and receptor activation patterns in experimental models
- Central melanocortin pathway-associated molecular markers observed in animal studies
- cAMP-mediated downstream signaling components in receptor pharmacology studies
- Hypothalamic signaling pathway components evaluated under experimental conditions
- Comparative receptor selectivity profiles relative to native α-MSH and Melanotan II
All reported applications are confined to descriptive investigation within controlled laboratory research environments.
Mechanistic discussions in preclinical publications describe PT-141 as the active metabolic product of Melanotan II following C-terminal deamidation. The free carboxyl terminus is described as contributing to differential receptor subtype selectivity. These descriptions are limited to molecular and biochemical observations within experimental systems and do not imply functional outcomes.
PT-141 is supplied as a research-grade peptide material. Identity and composition have been reported as characterized using analytical techniques commonly applied to peptide research materials, including chromatographic and mass spectrometric methods. Individual laboratories determine handling, storage, and analytical verification parameters in accordance with internal research protocols.
COA
Storage
All of our products are manufactured using the Lyophilization (Freeze Drying) process, which ensures that our products remain 100% stable for shipping for up to 3-4 months. Once the peptides are reconstituted (mixed with bacteriostatic water), they must be stored in the fridge to maintain stability. After reconstitution, the peptides will remain stable for up to 30 days.
Lyophilization is a unique dehydration process, also known as cryodesiccation, where the peptides are frozen and then subjected to low pressure. This causes the water in the peptide vial to sublimate directly from solid to gas, leaving behind a stable, crystalline white structure known as lyophilized peptide. The puffy white powder can be stored at room temperature until you're ready to reconstitute it with bacteriostatic water.
Once peptides have been received, it is imperative that they are kept cold and away from light. If the peptides will be used immediately, or in the next several days, weeks or months, short-term refrigeration under 4°C (39°F) is generally acceptable. Lyophilized peptides are usually stable at room temperatures for several weeks or more, so if they will be utilized within weeks or months such storage is typically adequate.
For longer term storage (several months to years) it is more preferable to store peptides in a freezer at -80°C (-112°F). When storing peptides for months or even years, freezing is optimal in order to preserve the peptide's stability.
Lyophilization is a unique dehydration process, also known as cryodesiccation, where the peptides are frozen and then subjected to low pressure. This causes the water in the peptide vial to sublimate directly from solid to gas, leaving behind a stable, crystalline white structure known as lyophilized peptide. The puffy white powder can be stored at room temperature until you're ready to reconstitute it with bacteriostatic water.
Once peptides have been received, it is imperative that they are kept cold and away from light. If the peptides will be used immediately, or in the next several days, weeks or months, short-term refrigeration under 4°C (39°F) is generally acceptable. Lyophilized peptides are usually stable at room temperatures for several weeks or more, so if they will be utilized within weeks or months such storage is typically adequate.
For longer term storage (several months to years) it is more preferable to store peptides in a freezer at -80°C (-112°F). When storing peptides for months or even years, freezing is optimal in order to preserve the peptide's stability.
