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NAD+ 1000mg
$300.00
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NAD+ 1000mg
NAD⁺ (nicotinamide adenine dinucleotide) is an essential cellular coenzyme involved in redox metabolism and energy production across all living systems. It functions as a critical electron carrier by cycling between its oxidized (NAD⁺) and reduced (NADH) states, enabling mitochondrial oxidative phosphorylation and glycolytic energy transfer in experimental models. Beyond its metabolic role, NAD⁺ serves as a required substrate for sirtuins and poly(ADP-ribose) polymerases (PARPs), enzymes involved in DNA repair, gene expression regulation, and cellular stress responses. Preclinical research utilizes NAD⁺ to investigate mitochondrial homeostasis, muscle metabolism, neuroprotection, and molecular mechanisms associated with aging and cellular resilience.
For research use only. Not for human consumption.
Product Overview
This peptide is produced in a controlled laboratory environment using validated synthesis and purification protocols to ensure high purity and consistency. Each batch is carefully processed to meet strict internal quality standards.
Quality & Testing
Manufactured under sterile conditions and independently tested to verify purity, composition, and integrity. Analytical methods may include HPLC and mass spectrometry to confirm specifications prior to release.
Intended Use
For research and laboratory use only. Not intended for human or veterinary use. Not for diagnostic, therapeutic, or consumptive purposes.
Handling & Storage
Store in a cool, dry environment away from direct light. Handle using appropriate laboratory safety procedures.
Properties
1. Basic Information
2. Structural Properties
Nature: Dinucleotide composed of adenosine monophosphate and nicotinamide mononucleotide joined by a pyrophosphate bond
Oxidation States: Exists as NAD+ (oxidized) and NADH (reduced); NAD+ is the oxidized form
Charge: Net negative charge at physiological pH due to phosphate groups
Conformation: Flexible molecule capable of adopting multiple conformations in solution
3. Solubility
4. Stability
Thermal Stability: Degrades rapidly above 37°C in solution; lyophilized form more stable
pH Stability: Most stable at pH 6–7; degrades rapidly above pH 8
Light Sensitivity: Sensitive to UV light; store in amber vials or dark conditions
Storage: Store lyophilized at −20°C; use reconstituted solution promptly
5. Chemical Reactivity
Functions as a hydride acceptor in oxidation-reduction reactions
Substrate for sirtuins (SIRT1–7), PARP enzymes, and CD38
Pyrophosphate bond susceptible to hydrolysis under acidic or basic conditions
Nicotinamide group participates directly in electron transfer reactions
6. Other Properties
- Name: Nicotinamide Adenine Dinucleotide (NAD+)
- Type: Coenzyme / dinucleotide
- Length: N/A — small molecule, not a peptide
- Molecular Weight: 663.43 Da
- Formula: C₂₁H₂₇N₇O₁₄P₂
- CAS Number: 53-84-9
2. Structural Properties
Nature: Dinucleotide composed of adenosine monophosphate and nicotinamide mononucleotide joined by a pyrophosphate bond
Oxidation States: Exists as NAD+ (oxidized) and NADH (reduced); NAD+ is the oxidized form
Charge: Net negative charge at physiological pH due to phosphate groups
Conformation: Flexible molecule capable of adopting multiple conformations in solution
3. Solubility
- Highly soluble in water
- Stable in neutral to slightly acidic aqueous solution
- Sensitive to alkaline conditions and high temperatures
- Supplied as lyophilized powder for reconstitution
4. Stability
Thermal Stability: Degrades rapidly above 37°C in solution; lyophilized form more stable
pH Stability: Most stable at pH 6–7; degrades rapidly above pH 8
Light Sensitivity: Sensitive to UV light; store in amber vials or dark conditions
Storage: Store lyophilized at −20°C; use reconstituted solution promptly
5. Chemical Reactivity
Functions as a hydride acceptor in oxidation-reduction reactions
Substrate for sirtuins (SIRT1–7), PARP enzymes, and CD38
Pyrophosphate bond susceptible to hydrolysis under acidic or basic conditions
Nicotinamide group participates directly in electron transfer reactions
6. Other Properties
- Central role in cellular energy metabolism as electron carrier in glycolysis and oxidative phosphorylation
- Sirtuin substrate: Investigated extensively in relation to mitochondrial biogenesis and cellular aging models
- PARP substrate: Involved in DNA repair signaling pathways in experimental systems
- Precursor relationships: Biosynthesized from tryptophan, nicotinic acid, and nicotinamide in cellular systems
Description
NAD+ (Nicotinamide Adenine Dinucleotide) is a naturally occurring coenzyme found in all living cells and has been described extensively in the scientific literature as a central mediator of cellular energy metabolism. Publications discussing NAD+ address it in the context of oxidation-reduction reactions, sirtuin activation, and DNA repair signaling within experimental systems.
Reports involving NAD+ describe its role as an electron carrier in glycolysis and oxidative phosphorylation under defined experimental conditions. Observations of NAD+-dependent enzyme activity and associated molecular interactions are reported as descriptive findings within cellular and animal model studies.
All references to NAD+ in a research context are confined to mechanistic and observational frameworks and do not extend beyond laboratory-based investigation.
In the scientific literature, NAD+ has been referenced extensively in non-clinical research involving cellular assays, enzyme kinetics studies, and animal model investigations. These publications describe experimental contexts in which molecular interactions, signaling components, and metabolic pathway markers were observed and recorded.
Reported research contexts include examination of:
- Sirtuin (SIRT1–7) enzyme activation and associated gene expression patterns
- PARP-dependent DNA repair signaling components in cellular models
- Mitochondrial biogenesis-associated molecular markers in experimental systems
- CD38-associated NAD+ consumption dynamics observed in laboratory settings
- Cellular energy metabolism pathway components measured under experimental conditions
- NAD+/NADH ratio dynamics evaluated in cellular and animal model systems
All reported applications are confined to descriptive investigation within controlled laboratory research environments.
Mechanistic discussions in preclinical publications describe NAD+ in relation to aging-associated molecular changes, mitochondrial function markers, and stress-response signaling networks. These descriptions are limited to molecular and biochemical observations within experimental systems and do not imply functional outcomes.
NAD+ is supplied as a research-grade material. Identity and composition have been reported as characterized using analytical techniques commonly applied to biochemical research materials, including chromatographic and spectrophotometric methods. Individual laboratories determine handling, storage, and analytical verification parameters in accordance with internal research protocols.
COA
Storage
All of our products are manufactured using the Lyophilization (Freeze Drying) process, which ensures that our products remain 100% stable for shipping for up to 3-4 months. Once the peptides are reconstituted (mixed with bacteriostatic water), they must be stored in the fridge to maintain stability. After reconstitution, the peptides will remain stable for up to 30 days.
Lyophilization is a unique dehydration process, also known as cryodesiccation, where the peptides are frozen and then subjected to low pressure. This causes the water in the peptide vial to sublimate directly from solid to gas, leaving behind a stable, crystalline white structure known as lyophilized peptide. The puffy white powder can be stored at room temperature until you're ready to reconstitute it with bacteriostatic water.
Once peptides have been received, it is imperative that they are kept cold and away from light. If the peptides will be used immediately, or in the next several days, weeks or months, short-term refrigeration under 4°C (39°F) is generally acceptable. Lyophilized peptides are usually stable at room temperatures for several weeks or more, so if they will be utilized within weeks or months such storage is typically adequate.
For longer term storage (several months to years) it is more preferable to store peptides in a freezer at -80°C (-112°F). When storing peptides for months or even years, freezing is optimal in order to preserve the peptide's stability.
Lyophilization is a unique dehydration process, also known as cryodesiccation, where the peptides are frozen and then subjected to low pressure. This causes the water in the peptide vial to sublimate directly from solid to gas, leaving behind a stable, crystalline white structure known as lyophilized peptide. The puffy white powder can be stored at room temperature until you're ready to reconstitute it with bacteriostatic water.
Once peptides have been received, it is imperative that they are kept cold and away from light. If the peptides will be used immediately, or in the next several days, weeks or months, short-term refrigeration under 4°C (39°F) is generally acceptable. Lyophilized peptides are usually stable at room temperatures for several weeks or more, so if they will be utilized within weeks or months such storage is typically adequate.
For longer term storage (several months to years) it is more preferable to store peptides in a freezer at -80°C (-112°F). When storing peptides for months or even years, freezing is optimal in order to preserve the peptide's stability.
