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TESAMORELIN 20mg
$325.00
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TESAMORELIN 20mg
Tesamorelin is a synthetic research peptide and stabilized analog of growth hormone–releasing hormone (GHRH) designed to selectively activate the GHRH receptor and stimulate endogenous growth hormone secretion in experimental models. Preclinical and clinical research has focused on its role in modulating somatotropic signaling, lipid metabolism, and visceral adipose regulation through cAMP-dependent pituitary pathways. Tesamorelin is utilized in research investigating hypothalamic–pituitary axis dynamics, metabolic signaling, neuroendocrine regulation, and growth hormone–mediated tissue effects.
Here’s a breakdown:
What It Does
Tesamorelin binds to GHRH receptors in the pituitary gland, stimulating growth hormone secretion. This, in turn, increases insulin-like growth factor 1 (IGF-1) levels in the blood — the main mediator of GH’s anabolic (muscle-building and fat-burning) effects.
Medical Use
Tesamorelin is FDA-approved under the brand name Egrifta® for:
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Reducing excess abdominal fat in HIV-associated lipodystrophy (fat accumulation due to antiretroviral therapy).
Off-Label / Research Uses
In the performance and anti-aging world, it’s often explored for:
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Reducing visceral and subcutaneous fat
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Improving muscle tone and recovery
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Enhancing sleep and cognitive function
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Improving skin elasticity and tissue repair
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Supporting natural GH levels in older adults
Administration
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Usually injected subcutaneously (under the skin) once daily.
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Common research doses: 1–2 mg per day, often before bedtime on an empty stomach to align with natural GH release.
Potential Side Effects
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Temporary injection site redness or irritation
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Water retention, mild joint pain, or carpal tunnel–like symptoms
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Insulin resistance or mild blood sugar elevation
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Nausea or tingling in hands/fingers
Half-Life & Onset
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Half-life: ~2 hours
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GH elevation peaks about 1–2 hours post-injection
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IGF-1 increase is gradual over days to weeks
Properties
1. Basic Information
2. Structural Properties Peptide Nature: Linear peptide with trans-3-hexenoic acid modification at the N-terminus
Secondary Structure: Adopts α-helical conformation critical for receptor binding
Hydrophobicity: Moderately hydrophobic due to Ile (I), Leu (L), Phe (F), Met (M)
Charge: Positively charged at physiological pH due to multiple Arg and Lys residues
3. Solubility
4. Stability Thermal Stability: Sensitive to elevated temperatures; keep refrigerated after reconstitution
Proteolytic Stability: N-terminal modification confers resistance to DPP-IV cleavage
Storage: Store lyophilized at −20°C; reconstituted stable up to 30 days at 2–8°C
5. Chemical Reactivity Methionine (M) is susceptible to oxidation under aerobic conditions
Lysine (K) and Arginine (R) residues may undergo chemical modifications
N-terminal trans-3-hexenoic acid modification enhances plasma stability
Peptide bonds are stable at neutral pH; hydrolysis under strong acid or base
6. Other Properties
- Name: Tesamorelin (Trans-3-hexenoic acid GRF 1-44)
- Type: Synthetic growth hormone-releasing factor (GRF) analog
- Length: 44 amino acids
- Sequence: Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-Gln-Gln-Gly-Glu-Ser-Asn-Gln-Glu-Arg-Gly-Ala-Arg-Ala-Arg-Leu
- Molecular Weight: ~5 kDa (5135.8 Da)
- Formula: C₂₂₁H₃₆₆N₇₂O₆₇S
2. Structural Properties Peptide Nature: Linear peptide with trans-3-hexenoic acid modification at the N-terminus
Secondary Structure: Adopts α-helical conformation critical for receptor binding
Hydrophobicity: Moderately hydrophobic due to Ile (I), Leu (L), Phe (F), Met (M)
Charge: Positively charged at physiological pH due to multiple Arg and Lys residues
3. Solubility
- Soluble in sterile water or bacteriostatic water for injection
- Stable at neutral to slightly acidic pH
- Supplied as lyophilized powder for reconstitution
4. Stability Thermal Stability: Sensitive to elevated temperatures; keep refrigerated after reconstitution
Proteolytic Stability: N-terminal modification confers resistance to DPP-IV cleavage
Storage: Store lyophilized at −20°C; reconstituted stable up to 30 days at 2–8°C
5. Chemical Reactivity Methionine (M) is susceptible to oxidation under aerobic conditions
Lysine (K) and Arginine (R) residues may undergo chemical modifications
N-terminal trans-3-hexenoic acid modification enhances plasma stability
Peptide bonds are stable at neutral pH; hydrolysis under strong acid or base
6. Other Properties
- Amphipathic: Helical structure allows interaction with GHRH receptor on pituitary somatotrophs
- Bioactive: Stimulates endogenous growth hormone secretion in a pulsatile, physiological manner
Description
Tesamorelin is a synthetic analog of growth hormone-releasing hormone (GHRH) and has been described in the scientific literature as a stabilized peptide designed to mimic the activity of endogenous GHRH. Publications referencing Tesamorelin discuss it in the context of hypothalamic-pituitary signaling and growth hormone secretion dynamics within experimental systems.
Reports involving Tesamorelin describe its interaction with GHRH receptors on pituitary somatotroph cells under defined experimental conditions. Observations of receptor binding and downstream signaling components are limited to non-clinical research settings and are reported as descriptive findings within cellular and animal model studies.
All references to Tesamorelin are confined to mechanistic and observational research contexts and do not extend beyond laboratory-based investigation.
In the scientific literature, Tesamorelin has been referenced in non-clinical research involving cellular assays and animal model studies. These publications describe experimental contexts in which molecular interactions, signaling components, and pathway-associated markers were observed and recorded.
Reported research contexts include examination of:
- GHRH receptor binding and activation dynamics in experimental models
- Growth hormone secretion patterns observed in controlled animal studies
- IGF-1 pathway-associated molecular markers
- Metabolic parameter measurements in preclinical model systems
- Lipid metabolism-associated molecular markers evaluated in animal models
All reported applications are confined to descriptive investigation within controlled laboratory research environments.
Mechanistic discussions in preclinical publications describe Tesamorelin in relation to the hypothalamic-pituitary-somatotropic axis, with reported observations of pulsatile growth hormone release patterns under experimental conditions. These descriptions are limited to molecular and biochemical observations within experimental systems.
Tesamorelin is supplied as a research-grade peptide material. Identity and composition have been reported as characterized using analytical techniques commonly applied to peptide research materials, including chromatographic and mass spectrometric methods. Individual laboratories determine handling, storage, and analytical verification parameters in accordance with internal research protocols.
COA
Storage
All of our products are manufactured using the Lyophilization (Freeze Drying) process, which ensures that our products remain 100% stable for shipping for up to 3-4 months. Once the peptides are reconstituted (mixed with bacteriostatic water), they must be stored in the fridge to maintain stability. After reconstitution, the peptides will remain stable for up to 30 days.
Lyophilization is a unique dehydration process, also known as cryodesiccation, where the peptides are frozen and then subjected to low pressure. This causes the water in the peptide vial to sublimate directly from solid to gas, leaving behind a stable, crystalline white structure known as lyophilized peptide. The puffy white powder can be stored at room temperature until you're ready to reconstitute it with bacteriostatic water.
Once peptides have been received, it is imperative that they are kept cold and away from light. If the peptides will be used immediately, or in the next several days, weeks or months, short-term refrigeration under 4°C (39°F) is generally acceptable. Lyophilized peptides are usually stable at room temperatures for several weeks or more, so if they will be utilized within weeks or months such storage is typically adequate.
For longer term storage (several months to years) it is more preferable to store peptides in a freezer at -80°C (-112°F). When storing peptides for months or even years, freezing is optimal in order to preserve the peptide's stability.
Lyophilization is a unique dehydration process, also known as cryodesiccation, where the peptides are frozen and then subjected to low pressure. This causes the water in the peptide vial to sublimate directly from solid to gas, leaving behind a stable, crystalline white structure known as lyophilized peptide. The puffy white powder can be stored at room temperature until you're ready to reconstitute it with bacteriostatic water.
Once peptides have been received, it is imperative that they are kept cold and away from light. If the peptides will be used immediately, or in the next several days, weeks or months, short-term refrigeration under 4°C (39°F) is generally acceptable. Lyophilized peptides are usually stable at room temperatures for several weeks or more, so if they will be utilized within weeks or months such storage is typically adequate.
For longer term storage (several months to years) it is more preferable to store peptides in a freezer at -80°C (-112°F). When storing peptides for months or even years, freezing is optimal in order to preserve the peptide's stability.
