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MELANOTAN II (MT2 10mg)
$65.00
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MELANOTAN II (MT2 10mg)
Melanotan 2 is a synthetic cyclic heptapeptide (Ac-Nle-c[Asp-His-D-Phe-Arg-Trp-Lys]-NH₂) that functions as a potent nonselective melanocortin receptor agonist. It is employed in receptor binding and signal transduction studies exploring MC1R–MC5R-mediated cAMP activation and GPCR desensitization mechanisms. MT-II provides a research model for peptide–receptor pharmacology and neuroendocrine signaling dynamics.
For research use only. Not for human consumption.
Properties
1. Basic Information
2. Structural Properties
Peptide Nature: Cyclic peptide with lactam bridge between Asp and Lys residues
Secondary Structure: Constrained cyclic conformation mimicking the active core of α-MSH
Hydrophobicity: Moderately hydrophobic due to D-Phe and Trp residues
Charge: Positively charged at physiological pH due to Arg and His residues
3. Solubility
4. Stability
Thermal Stability: More stable than linear peptide analogs due to cyclic conformation
Proteolytic Stability: Cyclic structure and D-Phe substitution confer resistance to enzymatic degradation
Storage: Store lyophilized at −20°C; reconstituted solution stable up to 30 days at 2–8°C
5. Chemical Reactivity
Lactam bridge between Asp and Lys is chemically stable under physiological conditions
Tryptophan (Trp) residue susceptible to oxidation; protect from light and oxygen
D-Phe substitution prevents chymotrypsin cleavage, extending research utility
N-terminal acetylation and C-terminal amidation enhance stability
6. Other Properties
- Name: Melanotan II (MT-II)
- Type: Synthetic cyclic peptide analog of alpha-melanocyte stimulating hormone (α-MSH)
- Length: 7 amino acids (cyclic)
- Sequence: Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH₂
- Molecular Weight: 1024.18 Da
- Formula: C₅₀H₆₉N₁₅O₉
- CAS Number: 121062-08-6
2. Structural Properties
Peptide Nature: Cyclic peptide with lactam bridge between Asp and Lys residues
Secondary Structure: Constrained cyclic conformation mimicking the active core of α-MSH
Hydrophobicity: Moderately hydrophobic due to D-Phe and Trp residues
Charge: Positively charged at physiological pH due to Arg and His residues
3. Solubility
- Soluble in bacteriostatic water and dilute acetic acid
- Stable at slightly acidic pH
- Cyclic structure confers greater stability than linear α-MSH
- Supplied as lyophilized powder for reconstitution
4. Stability
Thermal Stability: More stable than linear peptide analogs due to cyclic conformation
Proteolytic Stability: Cyclic structure and D-Phe substitution confer resistance to enzymatic degradation
Storage: Store lyophilized at −20°C; reconstituted solution stable up to 30 days at 2–8°C
5. Chemical Reactivity
Lactam bridge between Asp and Lys is chemically stable under physiological conditions
Tryptophan (Trp) residue susceptible to oxidation; protect from light and oxygen
D-Phe substitution prevents chymotrypsin cleavage, extending research utility
N-terminal acetylation and C-terminal amidation enhance stability
6. Other Properties
- Melanocortin receptor agonist: Binds MC1R, MC3R, MC4R, and MC5R with high affinity in experimental systems
- Potency: Approximately 1000x more potent than native α-MSH in receptor binding assays
- Investigated in preclinical models examining pigmentation, energy homeostasis, and related signaling pathways
Description
Melanotan II (MT-II) is a synthetic cyclic peptide analog of alpha-melanocyte stimulating hormone (α-MSH) and has been described in the scientific literature as a potent melanocortin receptor agonist. Publications referencing Melanotan II discuss it in the context of melanocortin receptor pharmacology and pigmentation-associated signaling within experimental systems.
Reports involving Melanotan II describe its binding affinity at multiple melanocortin receptor subtypes under defined experimental conditions. Observations of receptor activation and downstream signaling components are limited to non-clinical research settings and are reported as descriptive findings within cellular and animal model studies.
All references to Melanotan II are confined to mechanistic and observational research contexts and do not extend beyond laboratory-based investigation.
In the scientific literature, Melanotan II has been referenced in non-clinical research involving receptor binding assays, cellular assays, and animal model studies. These publications describe experimental contexts in which molecular interactions, signaling components, and pathway-associated markers were observed and recorded.
Reported research contexts include examination of:
- Melanocortin receptor (MC1R, MC3R, MC4R, MC5R) binding dynamics in experimental models
- Melanogenesis-associated molecular markers observed in cellular systems
- cAMP signaling pathway components activated in receptor binding studies
- Energy homeostasis-associated molecular markers evaluated in animal models
- Pigmentation pathway gene expression patterns in cellular research settings
All reported applications are confined to descriptive investigation within controlled laboratory research environments.
Mechanistic discussions in preclinical publications describe Melanotan II in relation to melanocortin receptor signaling networks. The cyclic structure and D-Phe substitution are described as contributing to enhanced receptor binding potency and enzymatic stability relative to native α-MSH. These descriptions are limited to molecular and biochemical observations within experimental systems.
Melanotan II is supplied as a research-grade peptide material. Identity and composition have been reported as characterized using analytical techniques commonly applied to peptide research materials, including chromatographic and mass spectrometric methods. Individual laboratories determine handling, storage, and analytical verification parameters in accordance with internal research protocols.
COA
Storage
All of our products are manufactured using the Lyophilization (Freeze Drying) process, which ensures that our products remain 100% stable for shipping for up to 3-4 months. Once the peptides are reconstituted (mixed with bacteriostatic water), they must be stored in the fridge to maintain stability. After reconstitution, the peptides will remain stable for up to 30 days.
Lyophilization is a unique dehydration process, also known as cryodesiccation, where the peptides are frozen and then subjected to low pressure. This causes the water in the peptide vial to sublimate directly from solid to gas, leaving behind a stable, crystalline white structure known as lyophilized peptide. The puffy white powder can be stored at room temperature until you're ready to reconstitute it with bacteriostatic water.
Once peptides have been received, it is imperative that they are kept cold and away from light. If the peptides will be used immediately, or in the next several days, weeks or months, short-term refrigeration under 4°C (39°F) is generally acceptable. Lyophilized peptides are usually stable at room temperatures for several weeks or more, so if they will be utilized within weeks or months such storage is typically adequate.
For longer term storage (several months to years) it is more preferable to store peptides in a freezer at -80°C (-112°F). When storing peptides for months or even years, freezing is optimal in order to preserve the peptide's stability.
Lyophilization is a unique dehydration process, also known as cryodesiccation, where the peptides are frozen and then subjected to low pressure. This causes the water in the peptide vial to sublimate directly from solid to gas, leaving behind a stable, crystalline white structure known as lyophilized peptide. The puffy white powder can be stored at room temperature until you're ready to reconstitute it with bacteriostatic water.
Once peptides have been received, it is imperative that they are kept cold and away from light. If the peptides will be used immediately, or in the next several days, weeks or months, short-term refrigeration under 4°C (39°F) is generally acceptable. Lyophilized peptides are usually stable at room temperatures for several weeks or more, so if they will be utilized within weeks or months such storage is typically adequate.
For longer term storage (several months to years) it is more preferable to store peptides in a freezer at -80°C (-112°F). When storing peptides for months or even years, freezing is optimal in order to preserve the peptide's stability.
