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MOTS-C 20mg - Wholesale
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$100.00
Regular price
$185.00
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MOTS-C 20mg - Wholesale
MOTS-c is a research peptide derived from mitochondria and composed of 16 amino acids (Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg). Encoded within the mitochondrial 12S rRNA gene, it regulates cellular metabolism through AMPK activation and mitochondrial homeostasis in preclinical studies. MOTS-c is widely used in metabolic and aging research investigating mitochondrial signaling, stress adaptation, and energy regulation mechanisms.
For research use only. Not for human consumption.
Properties
1. Basic Information
- Name: MOTS-C (Mitochondrial Open Reading Frame of the 12S rRNA type-C)
- Type: Mitochondrial-derived peptide
- Length:16 amino acids
- Sequence: MRWQEMGYIFYPRKLR
- Molecular Weight:~2 kDa (~2170–2200 Da depending on modifications)
- Formula: Approx. C₉₈H₁₅₈N₂₆O₂₆S (based on peptide sequence)
- Soluble in aqueous buffers with some hydrophobic interactions.
- Stable in slightly acidic to neutral pH (pH 5–7)
- Can be lyophilized for storage
2. Structural Properties Peptide Nature: Linear peptide, not cyclic
Secondary Structure: Likely flexible in solution, can adopt α-helical conformations under certain environments.
Hydrophobicity: Moderately hydrophobic due to residues like Methionine (M), Tryptophan (W), Isoleucine (I), and Phenylalanine (F)
Charge: Positively charged at physiological pH (pI ~9.7) due to Arginine (R) and Lysine (K) residues
3. Solubility
4. Stability
Thermal Stability: Moderate; like most peptides, degraded at high temperatures (>40°C)
Proteolytic Stability: Sensitive to proteases (trypsin, chymotrypsin), but can be stabilized with modifications (acetylation, amidation)
Storage: Usually stored frozen at −20°C or −80°C in lyophilized form
5. Chemical Reactivity
Contains methionine (M), which is susceptible to oxidation Lysine (K) and Arginine (R) can undergo chemical modifications like methylation or acetylation Tyrosine (Y) can be phosphorylated under enzymatic conditions Peptide bonds are stable under neutral pH but hydrolyze under strong acid or base
6. Other Properties
- Amphipathic: Contains both hydrophobic and hydrophilic residues, which can allow membrane interactions
Bioactive: Interacts with mitochondrial and cytosolic targets to regulate metabolism, insulin sensitivity, and stress responses
Description
MOTS-c is a short peptide encoded within the mitochondrial genome and has been described in the scientific literature as a member of the mitochondrial-derived peptide (MDP) class. Publications discussing MDPs describe these peptides in the context of mitochondrial signaling and inter-organelle communication within experimental systems.
Reports involving MOTS-c describe its identification in cellular compartments including mitochondria and the nucleus under defined experimental conditions. Observations of peptide localization and molecular interactions are limited to non-clinical research settings and are reported as descriptive findings within cellular and animal model studies.
All references to MOTS-c are confined to mechanistic and observational research contexts and do not extend beyond laboratory-based investigation.
In the scientific literature, MOTS-c has been referenced in non-clinical research involving cellular assays and animal model studies. These publications describe experimental contexts in which molecular interactions, signaling components, and pathway-associated markers were observed and recorded.
Reported research contexts include examination of:
All reported applications are confined to descriptive investigation within controlled laboratory research environments.
Mechanistic discussions in preclinical publications describe MOTS-c in relation to intracellular signaling pathways associated with energy-sensing and stress-responsive molecular networks, including components of the AMPK signaling framework.
Additional references describe experimental observations of MOTS-c localization to the nucleus under defined laboratory conditions, alongside reported associations with transcriptional regulation of nuclear-encoded genes. These descriptions are limited to molecular and biochemical observations within experimental systems. All pathway-related descriptions are restricted to non-clinical research contexts and do not imply functional outcomes.
Preclinical studies cited in the scientific literature describe observations involving MOTS-c in cellular and animal model systems. Reported observations include measurements of signaling-associated proteins, metabolite profiles, and gene expression markers recorded under defined experimental conditions.
Additional publications describe associations between MOTS-c and molecular features observed in experimental models of metabolic stress and mitochondrial perturbation. All reported findings are restricted to the experimental systems employed.
MOTS-c is supplied as a research-grade peptide material. Identity and composition have been reported as characterized using analytical techniques commonly applied to peptide research materials, including chromatographic and mass spectrometric methods.
Individual laboratories determine handling, storage, and analytical verification parameters in accordance with internal research protocols.
Reports involving MOTS-c describe its identification in cellular compartments including mitochondria and the nucleus under defined experimental conditions. Observations of peptide localization and molecular interactions are limited to non-clinical research settings and are reported as descriptive findings within cellular and animal model studies.
All references to MOTS-c are confined to mechanistic and observational research contexts and do not extend beyond laboratory-based investigation.
In the scientific literature, MOTS-c has been referenced in non-clinical research involving cellular assays and animal model studies. These publications describe experimental contexts in which molecular interactions, signaling components, and pathway-associated markers were observed and recorded.
Reported research contexts include examination of:
- Mitochondrial signaling-associated molecular components
- Nuclear translocation phenomena under experimental conditions
- AMPK-associated signaling elements
- Metabolic pathway-related molecular markers
- Gene expression patterns evaluated in cellular and animal models
All reported applications are confined to descriptive investigation within controlled laboratory research environments.
Mechanistic discussions in preclinical publications describe MOTS-c in relation to intracellular signaling pathways associated with energy-sensing and stress-responsive molecular networks, including components of the AMPK signaling framework.
Additional references describe experimental observations of MOTS-c localization to the nucleus under defined laboratory conditions, alongside reported associations with transcriptional regulation of nuclear-encoded genes. These descriptions are limited to molecular and biochemical observations within experimental systems. All pathway-related descriptions are restricted to non-clinical research contexts and do not imply functional outcomes.
Preclinical studies cited in the scientific literature describe observations involving MOTS-c in cellular and animal model systems. Reported observations include measurements of signaling-associated proteins, metabolite profiles, and gene expression markers recorded under defined experimental conditions.
Additional publications describe associations between MOTS-c and molecular features observed in experimental models of metabolic stress and mitochondrial perturbation. All reported findings are restricted to the experimental systems employed.
MOTS-c is supplied as a research-grade peptide material. Identity and composition have been reported as characterized using analytical techniques commonly applied to peptide research materials, including chromatographic and mass spectrometric methods.
Individual laboratories determine handling, storage, and analytical verification parameters in accordance with internal research protocols.
COA
Storage
All of our products are manufactured using the Lyophilization (Freeze Drying) process, which ensures that our products remain 100% stable for shipping for up to 3-4 months. Once the peptides are reconstituted (mixed with bacteriostatic water), they must be stored in the fridge to maintain stability. After reconstitution, the peptides will remain stable for up to 30 days.
Lyophilization is a unique dehydration process, also known as cryodesiccation, where the peptides are frozen and then subjected to low pressure. This causes the water in the peptide vial to sublimate directly from solid to gas, leaving behind a stable, crystalline white structure known as lyophilized peptide. The puffy white powder can be stored at room temperature until you're ready to reconstitute it with bacteriostatic water.
Once peptides have been received, it is imperative that they are kept cold and away from light. If the peptides will be used immediately, or in the next several days, weeks or months, short-term refrigeration under 4°C (39°F) is generally acceptable. Lyophilized peptides are usually stable at room temperatures for several weeks or more, so if they will be utilized within weeks or months such storage is typically adequate.
For longer term storage (several months to years) it is more preferable to store peptides in a freezer at -80°C (-112°F). When storing peptides for months or even years, freezing is optimal in order to preserve the peptide's stability.
Lyophilization is a unique dehydration process, also known as cryodesiccation, where the peptides are frozen and then subjected to low pressure. This causes the water in the peptide vial to sublimate directly from solid to gas, leaving behind a stable, crystalline white structure known as lyophilized peptide. The puffy white powder can be stored at room temperature until you're ready to reconstitute it with bacteriostatic water.
Once peptides have been received, it is imperative that they are kept cold and away from light. If the peptides will be used immediately, or in the next several days, weeks or months, short-term refrigeration under 4°C (39°F) is generally acceptable. Lyophilized peptides are usually stable at room temperatures for several weeks or more, so if they will be utilized within weeks or months such storage is typically adequate.
For longer term storage (several months to years) it is more preferable to store peptides in a freezer at -80°C (-112°F). When storing peptides for months or even years, freezing is optimal in order to preserve the peptide's stability.
