{"product_id":"5-amino-1mq-wholesale","title":"5-AMINO-1MQ - Wholesale","description":"\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eOverview\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e5-Amino-1MQ (5-amino-1-methylquinolinium) is a synthetic, cell-permeable small molecule investigated as a selective inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme involved in the methylation of nicotinamide and regulation of NAD+ availability. It is classified as a research compound and is not FDA-approved. Current evidence is primarily derived from preclinical cell-based and animal studies.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eMechanism of Action\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eBy inhibiting NNMT, 5-Amino-1MQ preserves intracellular NAD+ levels by preventing the conversion of nicotinamide to 1-methylnicotinamide (1-MNA). Elevated NAD+ availability activates SIRT1 (sirtuin-1) pathways associated with mitochondrial biogenesis, fat oxidation, and metabolic flexibility. Simultaneously, higher S-adenosylmethionine (SAM) availability supports methylation-dependent gene expression and epigenetic regulation.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eResearch and Off-Label Applications\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eInvestigated for reduction of visceral and white adipose tissue, improved insulin sensitivity and glucose metabolism, preservation of lean muscle mass, enhancement of mitochondrial function and energy expenditure, and muscle strength and recovery support. A 2024 preclinical study published in Scientific Reports demonstrated additive improvements in grip strength and exercise endurance when combined with resistance training in aged mice.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eAdministration\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eResearch protocols use oral dosing of approximately 50 mg taken 1–3 times daily, or subcutaneous injection. Common research cycles are approximately 2 months on, followed by a 1-month washout period.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003ePotential Adverse Effects\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eGenerally well tolerated in available studies. Reported mild effects include nausea, fatigue, and dizziness. Long-term human safety data is not established.\u003c\/p\u003e","brand":"Aureon Bioscience","offers":[{"title":"Default Title","offer_id":46648002674846,"sku":null,"price":110.0,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0747\/1543\/1070\/files\/5-AMINO.png?v=1775569097","url":"https:\/\/checkout.aureonbioscience.com\/products\/5-amino-1mq-wholesale","provider":"Aureon Bioscience","version":"1.0","type":"link"}